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Publication : Mouse Col18a1 is expressed in a tissue-specific manner as three alternative variants and is localized in basement membrane zones.

First Author  Muragaki Y Year  1995
Journal  Proc Natl Acad Sci U S A Volume  92
Issue  19 Pages  8763-7
PubMed ID  7568013 Mgi Jnum  J:28734
Mgi Id  MGI:76276 Doi  10.1073/pnas.92.19.8763
Citation  Muragaki Y, et al. (1995) Mouse Col18a1 is expressed in a tissue-specific manner as three alternative variants and is localized in basement membrane zones. Proc Natl Acad Sci U S A 92(19):8763-7
abstractText  We have isolated overlapping cDNAs encoding the N-terminal non-triple-helical region of mouse alpha 1(XVIII) collagen and shown that three different variants of alpha 1(XVIII) collagen exist. Each of the three variants shows characteristic tissue-specific expression patterns. Immunohistochemical studies show positive staining for alpha 1(XVIII) collagen along the basement membrane zones of vessels in the intestinal villi, the choroid plexus, skin, liver, and kidney. Thus, we conclude that alpha 1(XVIII) collagen may interact (directly or indirectly) with components in basement membrane zones or on the basal surface of endothelial/epithelial cells.
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