| First Author | Zhang DH | Year | 1999 |
| Journal | Immunity | Volume | 11 |
| Issue | 4 | Pages | 473-82 |
| PubMed ID | 10549629 | Mgi Jnum | J:58199 |
| Mgi Id | MGI:1346931 | Doi | 10.1016/s1074-7613(00)80122-3 |
| Citation | Zhang DH, et al. (1999) Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3. Immunity 11(4):473-82 |
| abstractText | The cytokines IL-4, IL-5, and IL-13, secreted by Th2 cells, have distinct functions in the pathogenesis of asthma. We have previously shown that the transcription factor GATA-3 is expressed in Th2 but not Th1 cells. However, it was unclear whether GATA-3 controls the expression of all Th2 cytokines. Expression of a dominant-negative mutant of GATA-3 in mice in a T cell-specific fashion led to a reduction in the levels of all the Th2 cytokines IL-4, IL-5, and IL-13. Airway eosinophilia, mucus production, and IgE synthesis, all key features of asthma, were severely attenuated in the transgenic mice. Thus, targeting GATA-3 activity alone is sufficient to blunt Th2 responses in vivo, thereby establishing GATA-3 as a potential therapeutic target in the treatment of asthma and allergic diseases. |
