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Publication : G(O), a guanine nucleotide binding protein, is expressed during neurite extension in the embryonic mouse.

First Author  Schmidt CJ Year  1994
Journal  J Neurosci Res Volume  38
Issue  2 Pages  182-7
PubMed ID  8078103 Mgi Jnum  J:18498
Mgi Id  MGI:66779 Doi  10.1002/jnr.490380208
Citation  Schmidt CJ, et al. (1994) G(O), a guanine nucleotide binding protein, is expressed during neurite extension in the embryonic mouse. J Neurosci Res 38(2):182-7
abstractText  The developmental pattern of expression of the G protein alpha o subunit and GAP43 were compared by immunohistochemical staining of mouse embryos. Staining for alpha o and GAP43 was identical and detected throughout the developing nervous system, and the antigens first appeared in neurons at the beginning of neuronal differentiation. GAP43 and alpha o were not detected in regions containing only neuroblasts. These observations suggest that alpha o and GAP43 may not be required for the decision to pass from neuroblast to differentiated neuron, but may play a role in signal transduction during early neuronal development.
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