| First Author | Wadhwa R | Year | 2002 |
| Journal | Exp Cell Res | Volume | 274 |
| Issue | 2 | Pages | 246-53 |
| PubMed ID | 11900485 | Mgi Jnum | J:75893 |
| Mgi Id | MGI:2178004 | Doi | 10.1006/excr.2002.5468 |
| Citation | Wadhwa R, et al. (2002) Hsp70 Family Member, mot-2/mthsp70/GRP75, Binds to the Cytoplasmic Sequestration Domain of the p53 Protein. Exp Cell Res 274(2):246-53 |
| abstractText | Hsp70 family member mot-2/mthsp70/GRP75/PBP74 was shown to bind to the tumor suppressor protein p53. In this study, by in vivo coimmunoprecipitation of mot-2 with p53 and its deletion mutants, the mot-2 binding site of p53 was mapped to its C-terminal amino acid residues 312-352, a region of p53 that includes its cytoplasmic sequestration domain. These data demonstrate that cytoplasmic sequestration and inactivation of p53 by mot-2 occurs by its binding to the cytoplasmic sequestration domain. Therefore, perturbation of mot-p53 interactions can be employed to abrogate cytoplasmic retention of wild-type p53 in tumors. (c)2002 Elsevier Science (USA). |
