| First Author | Pantaleon M | Year | 2003 |
| Journal | Reprod Fertil Dev | Volume | 15 |
| Issue | 1-2 | Pages | 37-45 |
| PubMed ID | 12729502 | Mgi Jnum | J:84286 |
| Mgi Id | MGI:2667274 | Doi | 10.1071/rd02031 |
| Citation | Pantaleon M, et al. (2003) The role of insulin-like growth factor II and its receptor in mouse preimplantation development. Reprod Fertil Dev 15(1):37-45 |
| abstractText | Insulin-like growth factor II (IGF-II) and its receptor, the IGF-II/mannose-6-phosphate (IGF-II/M6P) receptor, are first expressed from the zygotic genome at the two-cell stage of mouse development. However, their role is not clearly defined. Insulin-like growth factor II is believed to mediate growth through the heterologous type 1 IGF and insulin receptors, whereas the IGF-II/M6P receptor is believed to act as a negative regulator of somatic growth by limiting the availability of excess levels of IGF-II. These studies demonstrate that IGF-II does have a role in growth regulation in the early embryo through the IGF-II/M6P receptor. Insulin-like growth factor II stimulated cleavage rate in two-cell embryos in vitro. Moreover, this receptor is required for the glycaemic response of two-cell embryos to IGF-II and for normal progression of early embryos to the blastocyst stage. Improved development of embryos in crowded culture supports the concept of an endogenous embryonic paracrine activity that enhances cell proliferation. These responses indicate that the IGF-II/M6P receptor is functional and likely to participate in such a regulatory circuit. The functional role of IGF-II and its receptor is discussed with reference to regulation of early development. |
