| First Author | Phippard DJ | Year | 1996 |
| Journal | Development | Volume | 122 |
| Issue | 9 | Pages | 2729-37 |
| PubMed ID | 8787747 | Mgi Jnum | J:35807 |
| Mgi Id | MGI:83251 | Doi | 10.1242/dev.122.9.2729 |
| Citation | Phippard DJ, et al. (1996) Regulation of Msx-1, Msx-2, Bmp-2 and Bmp-4 during foetal and postnatal mammary gland development. Development 122(9):2729-37 |
| abstractText | Expression of the Msx-1 and Msx-2 homeobox genes have been shown to be coordinately regulated with the Bmp-2 and Bmp-4 ligands in a variety of developing tissues. Here we report that transcripts from all four genes are developmentally regulated during both foetal and postnatal mammary gland development. The location and time-course of the Bmp and Msx expression point to a role for Msx and Bmp gene products in the control of epithelial-mesenchymal interactions. Expression of Msx-2, but not Msx-1, Bmp-2 or Bmp-4 was decreased following ovariectomy, while expression of the human Msx-2 homologue was regulated by 17beta-oestradiol in the MCF-7 breast cancer cell line. The regulation of Msx-2 expression by oestrogen raises the possibility that hormonal regulation of mammary development is mediated through the control of epithelial-mesenchymal interactions. |
