| First Author | Bowen H | Year | 2002 |
| Journal | Biochem Soc Trans | Volume | 30 |
| Issue | 4 | Pages | 774-7 |
| PubMed ID | 12196193 | Mgi Jnum | J:78823 |
| Mgi Id | MGI:2386345 | Doi | 10.1042/BST0300774 |
| Citation | Bowen H, et al. (2002) c-Myc represses the murine Nramp1 promoter. Biochem Soc Trans 30(4):774-7 |
| abstractText | The Nramp1 (natural resistance-associated macrophage protein 1) gene modulates the growth of intracellular pathogens and encodes a divalent cation transporter within lysosomes/late endosomes of macrophages. Nramp1 modulates the cytoplasmic iron pool. Wu, Polack and Dalla-Favera [(1999) Science 283, 676-679] showed reciprocal control of H-ferritin and IRP2 by c-Myc, and suggest that c-Myc regulates genes to increase cytoplasmic iron. A role for c-Myc in Nramp1 regulation was evaluated. Co-transfection studies show that c-Myc represses Nramp1 promoter function. Five non-canonical Myc-max binding sites (E-box) identified within the Nramp1 5'-flanking sequence are not responsible for the inhibitory effects of c-Myc on Nramp1 expression. An initiator(s) adjacent to the transcription-initiation site is a candidate for the inhibition observed. Results are consistent with a role for Nramp1 removing iron from the cytosol and antagonizing c-Myc function. |
