| First Author | Liu HL | Year | 2002 |
| Journal | Brain Res | Volume | 948 |
| Issue | 1-2 | Pages | 175-9 |
| PubMed ID | 12383972 | Mgi Jnum | J:79270 |
| Mgi Id | MGI:2387719 | Doi | 10.1016/s0006-8993(02)03146-3 |
| Citation | Liu HL, et al. (2002) Immunocytochemical localization of substance P receptor in hypothalamic oxytocin-containing neurons of C57 mice. Brain Res 948(1-2):175-9 |
| abstractText | With the use of double immunofluorescence, we have examined the distribution of oxytocin-containing neurons that express substance P receptor (SPR) in the hypothalamus of C57 mice. The distribution of oxytocin-like immunoreactive neurons overlapped with that of SPR-like immunoreactive neurons in the paraventricular nucleus and supraoptic nucleus of the hypothalamus. Neurons showing both oxytocin- and SPR-like immunoreactivities were predominantly found in both nuclei. A few neurons that were double-labeled with oxytocin- and SPR-like immunoreactivities were also scattered in the hypothalamic periventricular and preoptic regions. Semi-quantitative analysis indicated that about 94% of the oxytocin-like neurons displayed SPR-like immunoreactivity. These double-labeled cells constituted about 91% of the SPR-like neurons in the aforementioned regions. The present study provides morphological evidence for tachykinin-induced modulation of oxytocin-containing neurons as mediated by substance P receptor in the hypothalamus of mammals. |
