| First Author | Yamaguchi M | Year | 1995 |
| Journal | Endocrinology | Volume | 136 |
| Issue | 5 | Pages | 2040-6 |
| PubMed ID | 7720652 | Mgi Jnum | J:25699 |
| Mgi Id | MGI:73409 | Doi | 10.1210/endo.136.5.7720652 |
| Citation | Yamaguchi M, et al. (1995) Cyclic adenosine 3',5'-monophosphate stimulation of placental proliferin and proliferin-related protein secretion. Endocrinology 136(5):2040-6 |
| abstractText | To identify factors that regulate proliferin (PLF) and PLF-related protein (PRP) secretion by the mouse placenta, placental cells from day 9 of pregnancy were cultured for up to 5 days, and PLF and PRP release into the medium was assessed by RIA. Transforming growth factor-alpha, interleukin-1 alpha, and interleukin-6 did not regulate either PLF or PRP secretion. However, treatment of primary placental cell cultures with 8-bromo-cAMP, cholera toxin, or forskolin resulted in 2- to 3-fold increases in the percentages of PLF- and PRP-producing cells in the population and corresponding increases in both PLF and PRP messenger RNA and secreted protein. The increase in the number of PLF-producing cells was accompanied by an increase in the number of cells expressing both PLF and mouse placental lactogen-I. These data suggest that cAMP levels can regulate trophoblast giant cell differentiation and, consequently, the amount of PLF and PRP secretion. |
