| First Author | Nagai K | Year | 2005 |
| Journal | Brain Res Dev Brain Res | Volume | 157 |
| Issue | 1 | Pages | 103-6 |
| PubMed ID | 15939091 | Mgi Jnum | J:104568 |
| Mgi Id | MGI:3612318 | Doi | 10.1016/j.devbrainres.2005.03.011 |
| Citation | Nagai K, et al. (2005) A transcriptional repressor MeCP2 causing Rett syndrome is expressed in embryonic non-neuronal cells and controls their growth. Brain Res Dev Brain Res 157(1):103-6 |
| abstractText | An epigenetic key protein MeCP2 is thought to be expressed exclusively in mature neurons. Here, we show that MeCP2 is expressed in embryonic non-neuronal cells by immunocytochemistry and Western blotting, and that knockdown of MeCP2 levels using RNA interference reduces their proliferation. These findings suggest that MeCP2 is essential to non-neuronal cell growth during brain development, which may be associated with microcephaly of Rett syndrome patients with MeCP2 mutations. |
