| First Author | Zhang HS | Year | 2000 |
| Journal | Cell | Volume | 101 |
| Issue | 1 | Pages | 79-89 |
| PubMed ID | 10778858 | Mgi Jnum | J:320113 |
| Mgi Id | MGI:6869952 | Doi | 10.1016/S0092-8674(00)80625-X |
| Citation | Zhang HS, et al. (2000) Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF. Cell 101(1):79-89 |
| abstractText | We present evidence that Rb forms a repressor containing histone deacetylase (HDAC) and the hSWI/SNF nucleosome remodeling complex, which inhibits transcription of genes for cyclins E and A and arrests cells in the G1 phase of the cell cycle. Phosphorylation of Rb by cyclin D/cdk4 disrupts association with HDAC, relieving repression of the cyclin E gene and G1 arrest. However, the Rb-hSWI/SNF complex persists and is sufficient to maintain repression of the cyclin A and cdc2 genes, inhibiting exit from S phase. HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF then appear to maintain the order of cyclin E and A expression during the cell cycle, which in turn regulates exit from G1 and from S phase, respectively. |
