| First Author | Naji L | Year | 2011 |
| Journal | Biochem Biophys Res Commun | Volume | 409 |
| Issue | 1 | Pages | 96-102 |
| PubMed ID | 21565175 | Mgi Jnum | J:172440 |
| Mgi Id | MGI:5007843 | Doi | 10.1016/j.bbrc.2011.04.116 |
| Citation | Naji L, et al. (2011) ARHGAP30 is a Wrch-1-interacting protein involved in actin dynamics and cell adhesion. Biochem Biophys Res Commun 409(1):96-102 |
| abstractText | The atypical Rho GTPase Wrch-1 has been proposed roles in cell migration, focal adhesion dissolution, stress fibre break down and tight junction heterogeneity. A screen for Wrch-1 binding-partners identified the novel RhoGAP protein, ARHGAP30, as a Wrch-1 interactor. ARHGAP30 is related to the Cdc42- and Rac1-specific RhoGAP CdGAP, which was likewise found to bind Wrch-1. In contrast to CdGAP, ARHGAP30 serves as a Rac1- and RhoA-specific RhoGAP. Ectopic expression of ARHGAP30 results in membrane blebbing and dissolution of stress-fibres and focal adhesions. Our data suggest roles for ARHGAP30 and CdGAP in regulation of cell adhesion downstream of Wrch-1. |
