| First Author | Kim M | Year | 2010 |
| Journal | FEBS Lett | Volume | 584 |
| Issue | 18 | Pages | 3923-8 |
| PubMed ID | 20804755 | Mgi Jnum | J:164374 |
| Mgi Id | MGI:4833733 | Doi | 10.1016/j.febslet.2010.08.034 |
| Citation | Kim M, et al. (2010) Identification of ptpro as a novel target gene of Wnt signaling and its potential role as a receptor for Wnt. FEBS Lett 584(18):3923-8 |
| abstractText | Wnt/beta-catenin signaling plays critical roles in embryonic development and tissue homeostasis in adults by controlling the expression of target genes. We found that expression of ptpro, which encodes a protein tyrosine phosphatase receptor type O (PTPRO), was induced by Wnt/beta-catenin signaling in a T cell factor/lymphoid enhancer factor dependent manner. Biochemical assays found that PTPRO interacted with Wnt via its extracellular domain. In addition, ectopic expression of this extracellular domain inhibited Wnt-mediated reporter activity. These results suggest that ptpro is a target gene of Wnt/beta-catenin signaling and that PTPRO may function as a novel receptor for Wnt. |
