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Publication : Isolation and expression analysis of a novel human homologue of the Drosophila glial cells missing (gcm) gene.

First Author  Kanemura Y Year  1999
Journal  FEBS Lett Volume  442
Issue  2-3 Pages  151-6
PubMed ID  9928992 Mgi Jnum  J:52057
Mgi Id  MGI:1327757 Doi  10.1016/s0014-5793(98)01650-0
Citation  Kanemura Y, et al. (1999) Isolation and expression analysis of a novel human homologue of the Drosophila glial cells missing (gcm) gene. FEBS Lett 442(2-3):151-6
abstractText  A novel human homologue (GCMB) of the Drosophila glial cells missing gene (dGCM) was isolated using RACE. GCMB contained a gcm motif sequence and a nuclear targeting sequence similar to that of dGCM and mouse GCMb. Homology searches indicated that GCMB was located within chromosome 6p24.2. Transcripts of GCMB were detected by means of RT-PCR in fetal brain, normal adult kidney, 3/3 medulloblastomas, 1/3 gliomas and 4/8 non-neuroepithelial tumor cell lines. Our data suggest that humans have two homologues of gcm like mice and that human gcm genes form a novel family which may function not only during fetal development but also in the postnatal or pathological stage.
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