First Author | Kanemura Y | Year | 1999 |
Journal | FEBS Lett | Volume | 442 |
Issue | 2-3 | Pages | 151-6 |
PubMed ID | 9928992 | Mgi Jnum | J:52057 |
Mgi Id | MGI:1327757 | Doi | 10.1016/s0014-5793(98)01650-0 |
Citation | Kanemura Y, et al. (1999) Isolation and expression analysis of a novel human homologue of the Drosophila glial cells missing (gcm) gene. FEBS Lett 442(2-3):151-6 |
abstractText | A novel human homologue (GCMB) of the Drosophila glial cells missing gene (dGCM) was isolated using RACE. GCMB contained a gcm motif sequence and a nuclear targeting sequence similar to that of dGCM and mouse GCMb. Homology searches indicated that GCMB was located within chromosome 6p24.2. Transcripts of GCMB were detected by means of RT-PCR in fetal brain, normal adult kidney, 3/3 medulloblastomas, 1/3 gliomas and 4/8 non-neuroepithelial tumor cell lines. Our data suggest that humans have two homologues of gcm like mice and that human gcm genes form a novel family which may function not only during fetal development but also in the postnatal or pathological stage. |