| First Author | Liu X | Year | 2016 |
| Journal | FEBS Lett | Volume | 590 |
| Issue | 2 | Pages | 279-87 |
| PubMed ID | 26823173 | Mgi Jnum | J:230442 |
| Mgi Id | MGI:5760088 | Doi | 10.1002/1873-3468.12046 |
| Citation | vLiu X, et al. (2016) Activation of the cAMP/protein kinase A signalling pathway by coronin 1 is regulated by cyclin-dependent kinase 5 activity. FEBS Lett 590(2):279-87 |
| abstractText | Coronins constitute a family of conserved proteins expressed in all eukaryotes that have been implicated in the regulation of a wide variety of cellular activities. Recent work showed an essential role for coronin 1 in the modulation of the cAMP/PKA pathway in neurons through the interaction of coronin 1 with the G protein subtype Galphas in a stimulus-dependent manner, but the molecular mechanism regulating coronin 1-Galphas interaction remains unclear. We here show that phosphorylation of coronin 1 on Thr(418/424) by cyclin-dependent kinase (CDK) 5 activity was responsible for coronin 1-Galphas association and the modulation of cAMP production. Together these results show an essential role for CDK5 activity in promoting the coronin 1-dependent cAMP/PKA pathway. |
