| First Author | Hussain SA | Year | 2011 |
| Journal | EMBO Rep | Volume | 12 |
| Issue | 3 | Pages | 276-82 |
| PubMed ID | 21311558 | Mgi Jnum | J:200501 |
| Mgi Id | MGI:5508730 | Doi | 10.1038/embor.2011.3 |
| Citation | Hussain SA, et al. (2011) Determinants of laminin polymerization revealed by the structure of the alpha5 chain amino-terminal region. EMBO Rep 12(3):276-82 |
| abstractText | The polymerization of laminin into a cell-associated network--a key step in basement membrane assembly--is mediated by the laminin amino-terminal (LN) domains at the tips of the three short arms of the laminin alphabetagamma-heterotrimer. The crystal structure of a laminin alpha5LN-LE1-2 fragment shows that the LN domain is a beta-jelly roll with several elaborate insertions that is attached like a flower head to the stalk-like laminin-type epidermal growth factor-like tandem. A surface loop that is strictly conserved in the LN domains of all alpha-short arms is required for stable ternary association with the beta- and gamma-short arms in the laminin network. |
