| First Author | Sahin F | Year | 2010 |
| Journal | Int J Biol Sci | Volume | 6 |
| Issue | 2 | Pages | 116-28 |
| PubMed ID | 20224733 | Mgi Jnum | J:175343 |
| Mgi Id | MGI:5285162 | Doi | 10.7150/ijbs.6.116 |
| Citation | Sahin F, et al. (2010) E2F-1 has dual roles depending on the cell cycle. Int J Biol Sci 6(2):116-28 |
| abstractText | The E2F family of transcription factors play a critical role in the control of cell proliferation. E2F-1 is the major cellular target of pRB and is regulated by pRB during cell proliferation. E2F-1-mediated activation and repression of target genes occurs in different settings. The role of E2F-1 and E2F-1/pRB complexes in regulation of different target genes, and in cycling versus quiescent cells, is unclear. In this study, effects of free E2F-1 (doesn't complex with pRb) and E2F-1/pRb complex, on E2F-1 target gene expression were compared in different cell growth conditions. Findings suggest that E2F-1 acts in different ways, not only depending on the target gene but also depending on different stages of the cell cycle. For example, E2F-1 acts as part of the repression complex with pRB in the expression of DHFR, b-myb, TK and cdc2 in asynchronously growing cells; on the other hand, E2F-1 acts as an activator in the expression of the same genes in cells that are re-entering the cycle. |
