| First Author | Gordon CT | Year | 2005 |
| Journal | Biochim Biophys Acta | Volume | 1729 |
| Issue | 1 | Pages | 74-80 |
| PubMed ID | 15833715 | Mgi Jnum | J:210920 |
| Mgi Id | MGI:5572879 | Doi | 10.1016/j.bbaexp.2005.03.004 |
| Citation | Gordon CT, et al. (2005) C/EBPdelta and C/EBPgamma bind the CCAAT-box in the human beta-globin promoter and modulate the activity of the CACC-box binding protein, EKLF. Biochim Biophys Acta 1729(1):74-80 |
| abstractText | Developmental- and tissue-specific expression of globin genes is mediated by a few key elements within the proximal promoter of each gene. DNA-binding assays previously identified NF-Y, GATA-1, C/EBPbeta and C/EBPgamma as candidate regulators of beta-globin transcription via the CCAAT-box, a promoter element situated between CACC- and TATA-boxes. We have identified C/EBPdelta as an additional beta-globin CCAAT-box binding protein. In reporter assays, we show that C/EBPdelta can co-operate with EKLF, a CACC-box binding protein, to activate the beta-globin promoter, whereas C/EBPgamma inhibits the transcriptional activity of EKLF in this assay. |
