| First Author | Kanamori M | Year | 2002 |
| Journal | FEBS Lett | Volume | 532 |
| Issue | 1-2 | Pages | 241-6 |
| PubMed ID | 12459498 | Mgi Jnum | J:113967 |
| Mgi Id | MGI:3687919 | Doi | 10.1016/s0014-5793(02)03688-8 |
| Citation | Kanamori M, et al. (2002) NF-kappaB activator Act1 associates with IL-1/Toll pathway adaptor molecule TRAF6. FEBS Lett 532(1-2):241-6 |
| abstractText | NF-kappaB activator 1 (Act1), also called CIKS, is a recently identified protein with NF-kappaB and AP-1 activation activities through its association with the IkappaB kinase complex. We identified and confirmed that Act1 interacts with tumor necrosis factor receptor-associated factor 6 (TRAF6); notably, Act1 binds to TRAF6 only among TRAF family proteins. The amino-terminal half of Act1 is required for its interaction with the TRAF domain. Act1-mediated NF-kappaB activation was inhibited by a dominant-negative mutant of TRAF6 in a dose-dependent manner, and IL-1-induced NF-kappaB activation was inhibited by a high level of Act1 expression. Our results suggest that Act1 is involved in IL-1/Toll-mediated signaling through TRAF6. |
