| First Author | Harikrishnan KN | Year | 2005 |
| Journal | Nat Genet | Volume | 37 |
| Issue | 3 | Pages | 254-64 |
| PubMed ID | 15696166 | Mgi Jnum | J:118818 |
| Mgi Id | MGI:3700432 | Doi | 10.1038/ng1516 |
| Citation | Harikrishnan KN, et al. (2005) Brahma links the SWI/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencing. Nat Genet 37(3):254-64 |
| abstractText | Transcriptional repression of methylated genes can be mediated by the methyl-CpG binding protein MeCP2. Here we show that human Brahma (Brm), a catalytic component of the SWI/SNF-related chromatin-remodeling complex, associates with MeCP2 in vivo and is functionally linked with repression. We used a number of different molecular approaches and chromatin immunoprecipitation strategies to show a unique cooperation between Brm, BAF57 and MeCP2. We show that Brm and MeCP2 assembly on chromatin occurs on methylated genes in cancer and the gene FMR1 in fragile X syndrome. These experimental findings identify a new role for SWI/SNF in gene repression by MeCP2. |
