| First Author | Wang Y | Year | 2015 |
| Journal | FEBS Lett | Volume | 589 |
| Issue | 12 | Pages | 1322-30 |
| PubMed ID | 25907537 | Mgi Jnum | J:221417 |
| Mgi Id | MGI:5639149 | Doi | 10.1016/j.febslet.2015.04.019 |
| Citation | Wang Y, et al. (2015) TRIM35 negatively regulates TLR7- and TLR9-mediated type I interferon production by targeting IRF7. FEBS Lett 589(12):1322-30 |
| abstractText | Toll-like receptor 7 (TLR7) and TLR9 sense viral nucleic acids and induce type I IFN production, which must be properly controlled to avoid autoimmune diseases. Here, we report the negative regulation of TLR7/9-mediated type I IFN production by TRIM35. TRIM35 expression is induced by TLR7/9 stimulation and then interacts with IRF7, which is the master regulator of type I IFN response. Furthermore, TRIM35 promotes the K48-linked ubiquitination of IRF7 and induces its degradation via a proteasome-dependent pathway. Therefore, TRIM35 is a negative feedback regulator of TLR7/9-mediated type I IFN production due to its ability to suppress the stability of IRF7. |
