| First Author | Ruaro ME | Year | 2000 |
| Journal | FEBS Lett | Volume | 481 |
| Issue | 2 | Pages | 159-63 |
| PubMed ID | 10996316 | Mgi Jnum | J:180495 |
| Mgi Id | MGI:5306329 | Doi | 10.1016/s0014-5793(00)02005-6 |
| Citation | Ruaro ME, et al. (2000) Analysis of the domain requirement in Gas1 growth suppressing activity. FEBS Lett 481(2):159-63 |
| abstractText | The product of the growth arrest specific gene, gas1, is a membrane-associated protein which activates a p53-dependent growth suppression signalling pathway. We have shown that Gas1 is linked to the plasma membrane through a glycosyl-phosphatidylinositol (GPI) anchor. Several GPI-anchored protein have been identified as part of receptor complexes either as co-receptors or as membrane bound ligands. In this report, we characterize the Gas1 domains required for its growth suppression function and demonstrate the dispensability of Gas1 GPI anchor. |
