| First Author | Knolle MD | Year | 2009 |
| Journal | Expert Opin Ther Targets | Volume | 13 |
| Issue | 5 | Pages | 523-40 |
| PubMed ID | 19397475 | Mgi Jnum | J:172958 |
| Mgi Id | MGI:5009371 | Doi | 10.1517/14728220902889788 |
| Citation | Knolle MD, et al. (2009) ADAM8: a new therapeutic target for asthma. Expert Opin Ther Targets 13(5):523-40 |
| abstractText | BACKGROUND: A proteinase with a disintegrin and a metalloproteinase domain-8 (ADAM8) has been linked to asthma. OBJECTIVE: To explore whether ADAM8 is a therapeutic target for asthma. METHODS: We reviewed literature on ADAM8's function and expression and activities in lungs of humans and mice with allergic airway inflammation (AAI). We used these data to generate hypotheses about the contributions of ADAM8 to asthma pathogenesis. CONCLUSIONS: ADAM8 levels are increased in airway epithelium and airway inflammatory cells in mice with AAI and human asthma patients. Data from murine models of AAI indicate that ADAM8 dampens airway inflammation. It is not clear whether ADAM8 contributes directly to structural remodeling in asthmatic airways. Additional studies are required to validate ADAM8 as a therapeutic target for asthma. |
