| First Author | Higashiyama S | Year | 1991 |
| Journal | Science | Volume | 251 |
| Issue | 4996 | Pages | 936-9 |
| PubMed ID | 1840698 | Mgi Jnum | J:114809 |
| Mgi Id | MGI:3690187 | Doi | 10.1126/science.1840698 |
| Citation | Higashiyama S, et al. (1991) A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF. Science 251(4996):936-9 |
| abstractText | Macrophage-like U-937 cells secrete a 22-kilodalton heparin-binding growth factor that is mitogenic for BALB-3T3 fibroblasts and smooth muscle cells, but not endothelial cells. The amino acid sequence predicted from complementary DNA clones indicates that the mitogen is a new member of the epidermal growth factor (EGF) family. This heparin-binding EGF-like growth factor (HB-EGF) binds to EGF receptors on A-431 epidermoid carcinoma cells and smooth muscle cells, but is a far more potent mitogen for smooth muscle cells than is EGF. HB-EGF is also expressed in cultured human macrophages and may be involved in macrophage-mediated cellular proliferation. |
