| First Author | Shimshon L | Year | 2011 |
| Journal | FEBS Lett | Volume | 585 |
| Issue | 15 | Pages | 2405-9 |
| PubMed ID | 21722636 | Mgi Jnum | J:175905 |
| Mgi Id | MGI:5287918 | Doi | 10.1016/j.febslet.2011.06.022 |
| Citation | Shimshon L, et al. (2011) SUMOylation of Blimp-1 promotes its proteasomal degradation. FEBS Lett 585(15):2405-9 |
| abstractText | B lymphocyte induced maturation protein-1 (Blimp-1) is a transcription repressor of the Krueppel-like family. Blimp-1 plays important roles in developmental processes, such as of germ cells and hair follicle stem cells. In B lymphocytes Blimp-1 orchestrates the terminal differentiation into plasma cells. We discovered that Blimp-1 undergoes SUMOylation by SUMO-1. This SUMOylation is modulated by the SUMO protease SENP1. While Blimp-1 is relatively stable in 293T cells, a fusion with SUMO1 rendered it to rapid proteasomal degradation. Increase in SENP1 activity stabilized Blimp-1, while a decrease promoted its degradation. Our data indicate that SUMOylation of Blimp-1 regulates its intracellular stability. |
