| First Author | Singh SB | Year | 2006 |
| Journal | Science | Volume | 313 |
| Issue | 5792 | Pages | 1438-41 |
| PubMed ID | 16888103 | Mgi Jnum | J:112322 |
| Mgi Id | MGI:3656111 | Doi | 10.1126/science.1129577 |
| Citation | Singh SB, et al. (2006) Human IRGM induces autophagy to eliminate intracellular mycobacteria. Science 313(5792):1438-41 |
| abstractText | Immunity-related p47 guanosine triphosphatases (IRG) play a role in defense against intracellular pathogens. We found that the murine Irgm1 (LRG-47) guanosine triphosphatase induced autophagy and generated large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis. We also identified a function for a human IRG protein in the control of intracellular pathogens and report that the human Irgm1 ortholog, IRGM, plays a role in autophagy and in the reduction of intracellular bacillary load. |
