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Publication : Expression of the proteoglycan SPOCK during mouse embryo development.

First Author  Charbonnier F Year  2000
Journal  Mech Dev Volume  90
Issue  2 Pages  317-21
PubMed ID  10640720 Mgi Jnum  J:60423
Mgi Id  MGI:1353269 Doi  10.1016/s0925-4773(99)00255-5
Citation  Charbonnier F, et al. (2000) Expression of the proteoglycan SPOCK during mouse embryo development. Mech Dev 90(2):317-21
abstractText  SPOCK is a modular proteoglycan, with homology with proteins involved in cell adhesion processes and neurogenesis. We have previously shown that SPOCK transcripts predominate in the adult mouse brain. Here, we report its expression during mouse embryonic development by in situ hybridization, and immunocytochemistry. SPOCK is actively expressed at the onset of neurogenesis during periods of neuron migration and axonal outgrowth. At a later developmental stage, its expression is particularly prevalent within developing synaptic fields. In the peripheral nervous system, SPOCK expression is also developmentally regulated particularly in dorsal root ganglion neurons.
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