| First Author | Zeng Q | Year | 2003 |
| Journal | Cancer Res | Volume | 63 |
| Issue | 11 | Pages | 2716-22 |
| PubMed ID | 12782572 | Mgi Jnum | J:114797 |
| Mgi Id | MGI:3690175 | Citation | Zeng Q, et al. (2003) PRL-3 and PRL-1 promote cell migration, invasion, and metastasis. Cancer Res 63(11):2716-22 |
| abstractText | We demonstrate here that Chinese hamster ovary cells stably expressing PRL-3, a M(r) 20000 prenylated protein tyrosine phosphatase, or its relative, PRL-1, exhibit enhanced motility and invasive activity. A catalytically inactive PRL-3 mutant has significantly reduced migration-promoting activity. We observe that PRL-3 is associated with diverse membrane structures involved in cell movement. Furthermore, we show that PRL-3- and -1-expressing cells, but not control cells, induce metastatic tumor formation in mice. Thus, our results deliver the first evidence for a causative role of PRL-3 and -1 in promoting cell motility, invasion activity, and metastasis. |
