| First Author | Chen Y | Year | 2005 |
| Journal | Neuropharmacology | Volume | 49 |
| Issue | 7 | Pages | 1026-41 |
| PubMed ID | 16054660 | Mgi Jnum | J:200308 |
| Mgi Id | MGI:5508267 | Doi | 10.1016/j.neuropharm.2005.05.022 |
| Citation | Chen Y, et al. (2005) Interactions between CAP70 and actinfilin are important for integrity of actin cytoskeleton structures in neurons. Neuropharmacology 49(7):1026-41 |
| abstractText | The integrity of dynamic actin structures is coupled to a variety of neurological processes. Actin-binding proteins play a critical role in regulating actin structure dynamics. A link between actin-binding proteins and receptor interacting scaffolding proteins may provide a conduit for transmitting signaling events to the cytoskeleton. Actinfilin is a brain-enriched actin-binding protein, though its functions are currently unknown. We report here that actinfilin interacts with the multi-PDZ domain protein CAP70. Recombinant expression of an actin-binding domain of actinfilin progressively causes marked changes of cellular morphology. The effect on cell morphology may be reduced by co-expression with CAP70. Mutation of actinfilin lacking the ability to interact with CAP70 abolished the effect by CAP70. The evidence suggests a role of actinfilin and possible regulation by scaffolding proteins. |
