| First Author | Sugihara T | Year | 2001 |
| Journal | J Biol Chem | Volume | 276 |
| Issue | 22 | Pages | 18649-52 |
| PubMed ID | 11259404 | Mgi Jnum | J:143694 |
| Mgi Id | MGI:3828414 | Doi | 10.1074/jbc.C100011200 |
| Citation | Sugihara T, et al. (2001) Pex19p dampens the p19ARF-p53-p21WAF1 tumor suppressor pathway. J Biol Chem 276(22):18649-52 |
| abstractText | We isolated a 33-kDa protein, Pex19p/HK33/HsPXF, as a p19ARF-binding protein in a yeast two-hybrid screen. We demonstrate here that Pex19p interacts with p19ARF in the cell cytoplasm and excludes p19ARF from the nucleus, leading to a concurrent inactivation of p53 function. Down-regulation of Pex19p by its antisense expression resulted in increased levels of p19ARF, increased p53 function, and a p53/p21WAF1-mediated senescence-like cell cycle arrest. The data demonstrated a novel mechanism of down-regulation of the p19ARF-p53 pathway. |
