| First Author | Zhu C | Year | 2005 |
| Journal | Nat Immunol | Volume | 6 |
| Issue | 12 | Pages | 1245-52 |
| PubMed ID | 16286920 | Mgi Jnum | J:112653 |
| Mgi Id | MGI:3662972 | Doi | 10.1038/ni1271 |
| Citation | Zhu C, et al. (2005) The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. Nat Immunol 6(12):1245-52 |
| abstractText | Tim-3 is a T helper type 1 (T(H)1)-specific cell surface molecule that seems to regulate T(H)1 responses and the induction of peripheral tolerance. However, the identity of the Tim-3 ligand and the mechanism by which this ligand inhibits the function of effector T(H)1 cells remain unknown. Here we show that galectin-9 is the Tim-3 ligand. Galectin-9-induced intracellular calcium flux, aggregation and death of T(H)1 cells were Tim-3-dependent in vitro, and administration of galectin-9 in vivo resulted in selective loss of interferon-gamma-producing cells and suppression of T(H)1 autoimmunity. These data suggest that the Tim-3-galectin-9 pathway may have evolved to ensure effective termination of effector T(H)1 cells. |
