| First Author | Ho SR | Year | 2010 |
| Journal | FEBS Lett | Volume | 584 |
| Issue | 1 | Pages | 49-54 |
| PubMed ID | 19932102 | Mgi Jnum | J:200381 |
| Mgi Id | MGI:5508575 | Doi | 10.1016/j.febslet.2009.11.059 |
| Citation | Ho SR, et al. (2010) O-GlcNAcylation enhances FOXO4 transcriptional regulation in response to stress. FEBS Lett 584(1):49-54 |
| abstractText | The FOXO4 transcription factor plays an important role in cell survival in response to oxidative stress. The regulation of FOXO4 is orchestrated by post-translational modifications including phosphorylation, acetylation, and ubiquitination. Here, we demonstrate that O-GlcNAcylation also contributes to the FOXO4-dependent oxidative stress response. We show that hydrogen peroxide treatment of HEK293 cells increases FOXO4 association with OGT, the enzyme that adds O-GlcNAc to proteins, causing FOXO4 O-GlcNAcylation and enhanced transcriptional activity under acute oxidative stress. O-GlcNAcylation is known to be protective for cells under stress conditions, including oxidative stress. Our data provide a mechanism of FOXO4 anti-oxidative protection through O-GlcNAcylation. |
