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Publication : Avoidance learning in autoimmune mice.

First Author  Balogh SA Year  2000
Journal  Brain Res Volume  887
Issue  2 Pages  484-7
PubMed ID  11134648 Mgi Jnum  J:66549
Mgi Id  MGI:1928610 Doi  10.1016/s0006-8993(00)03064-x
Citation  Baloght SA, et al. (2000) Avoidance learning in autoimmune mice. Brain Res 887(2):484-7
abstractText  Previous studies have shown that autoimmune mice perform very poorly on active avoidance learning tasks. In the current studies, mice with lupus-like systemic autoimmunity were able to learn active, as well as passive, avoidance protocols with shock as reinforcement. Therefore, the behavioral deficits seen in active avoidance tasks are not a consequence of the use of electric shock. Rather, the current findings suggest that the inability of autoimmune mice to learn shock motivated responding is due to multiple performance factors, including shock level and properties of the testing apparatus.
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