| First Author | Feili-Hariri M | Year | 2001 |
| Journal | Clin Immunol | Volume | 98 |
| Issue | 1 | Pages | 133-42 |
| PubMed ID | 11141336 | Mgi Jnum | J:66869 |
| Mgi Id | MGI:1929368 | Doi | 10.1006/clim.2000.4959 |
| Citation | Feili-Hariri M, et al. (2001) Phenotypic and functional characteristics of BM-derived DC from NOD and non-diabetes-prone strains. Clin Immunol 98(1):133-42 |
| abstractText | We compared BM-derived DC from NOD with DC from non-diabetes-prone strains. NOD myeloid progenitors cultured in GM or GM + IL-4 yielded lower numbers of DC than similar cultures from other strains. NOD GM + IL-4 DC produced lower amounts of IL-12 p70 following CD40 ligation or LPS stimulation in the presence of IFN-gamma than DC from other strains, although similar levels of IL-6 and NO were produced by all strains. The low amounts of IL-12 p70 produced by GM + IL-4 DC are despite a more mature DC phenotype observed in NOD mice. The low DC number could diminish the ability of DC to stimulate immunoregulatory T cells. Furthermore, the differentiation/maturation of DC from myeloid progenitors is altered, reflecting disorders in the function of these cells in NOD BM. |
