| First Author | Roark CL | Year | 2001 |
| Journal | Clin Immunol | Volume | 98 |
| Issue | 1 | Pages | 95-103 |
| PubMed ID | 11141331 | Mgi Jnum | J:66868 |
| Mgi Id | MGI:1929367 | Doi | 10.1006/clim.2000.4950 |
| Citation | Roark CL, et al. (2001) Characterization of CD4(+) T cell autoreactivity to self-MHC in New Zealand hybrid mice. Clin Immunol 98(1):95-103 |
| abstractText | The New Zealand white (NZW) H2(z) locus is strongly associated with the development of autoimmune disease in (NZB x NZW)F(1) mice, a model of systemic lupus erythematosus. To better understand the role of H2(z) in autoimmunity, we generated CD4(+) T cell hybridomas from the spleen and lymph nodes of unimmunized (NZB x NZW)F(1) mice and characterized their specificity. We found that over 50% of the hybridomas responded to syngeneic (H2(d/z)) spleen cells in the absence of exogenous antigen. Many of these autoreactive hybridomas responded to spleen cells expressing H2(z) and used H2(z) class II (I-A(z) or I-E(z)) molecules for presentation. Interestingly, nearly one third of the H2(z)-reactive hybridomas could not respond to spleen cells expressing only H2(z) class II molecules. These studies characterize a frequent population of autoreactive CD4(+) T cells in lupus mice and indicate that major histocompatibility complex molecules in addition to class II may be important for this self-recognition. |
