| First Author | Kerksiek KM | Year | 2001 |
| Journal | J Immunol | Volume | 166 |
| Issue | 2 | Pages | 1132-40 |
| PubMed ID | 11145694 | Mgi Jnum | J:66848 |
| Mgi Id | MGI:1929347 | Doi | 10.4049/jimmunol.166.2.1132 |
| Citation | Kerksiek KM, et al. (2001) Variable immunodominance hierarchies for H2-M3-restricted N-formyl peptides following bacterial infection. J Immunol 166(2):1132-40 |
| abstractText | H2-M3-restricted presentation of N-formyl methionine (f-Met) peptides to CD8(+) T cells provides a mechanism for selective recognition of bacterial infection. In this report we demonstrate that Listeria monocytogenes infection induces distinct CD8(+) T cell populations specific for each of the known Listeria-derived formyl methionine peptides presented by M3. The sum H2-M3-restricted, Listeria-specific T cell response constitutes a major fraction of the total CD8(+) T cell response to primary infection. H2-M3-restricted T cell populations expand synchronously in vivo and achieve peak frequencies approximately 2 days earlier than MHC class Ia-restricted T cell populations. Although cross-recognition of different f-Met peptides by M3-restricted T cells was previously described, costaining of CD8(+) T cells ex vivo with H2-M3 tetramers complexed with different f-Met peptides shows that the majority of Listeria-specific, M3-restricted CD8(+) T cells are peptide specific. In contrast to the highly predictable size and immunodominance hierarchies of MHC class Ia-restricted T cell responses, the magnitudes of T cell responses specific for H2-M3-restricted peptides are remarkably variable between genetically identical mice. Our findings demonstrate that H2-M3-restricted T cell responses are distinct from classically restricted T cell responses to bacterial infection. |
