| First Author | Jackson AU | Year | 1999 |
| Journal | Genetics | Volume | 151 |
| Issue | 2 | Pages | 785-95 |
| PubMed ID | 9927469 | Mgi Jnum | J:52562 |
| Mgi Id | MGI:1329761 | Doi | 10.1093/genetics/151.2.785 |
| Citation | Jackson AU, et al. (1999) Multiple-trait quantitative trait loci analysis using a large mouse sibship. Genetics 151(2):785-95 |
| abstractText | Quantitative trait loci influencing several phenotypes were assessed using a genetically heterogeneous mouse population. The 145 individuals were produced by a cross between (BALB/cJ x C57BL/6J)F1 females and (C3H/HeJ x DBA/2J)F1 males. The population is genetically equivalent to full siblings derived from heterozygous parents, with known linkage phase. Each individual in the population represents a unique combination of alleles from the inbred grandparents. Quantitative phenotypes for eight T cell measures were obtained at 8 and 18 mo of age. Single-marker locus, repeated measures analysis of variance identified nine marker-phenotype associations with an experimentwise significance level of P < 0.05. Six of the eight quantitative phenotypes could be associated with at least one locus having experiment-wide significance. Composite interval, repeated measures analysis of variance identified 13 chromosomal regions with comparisonwise (nominal) significance associations of P < 0.001. The heterozygous-parent cross provides a reproducible, general method for identification of loci associated with quantitative trait phenotypes or repeated phenotypic measures. |
