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Publication : Xnkx-2.1: a homeobox gene expressed during early forebrain, lung and thyroid development in Xenopus laevis.

First Author  Hollemann T Year  2000
Journal  Dev Genes Evol Volume  210
Issue  11 Pages  579-81
PubMed ID  11180810 Mgi Jnum  J:65844
Mgi Id  MGI:1927374 Doi  10.1007/s004270050350
Citation  Hollemann T, et al. (2000) Xnkx-2.1: a homeobox gene expressed during early forebrain, lung and thyroid development in Xenopus laevis. Dev Genes Evol 210(11):579-81
abstractText  Nkx-2.1 is a member of the vertebrate Nkx family of homeobox genes; it was originally identified as a tissue-specific regulator of thyroglobulin and thyroperoxidase gene transcription. Here we report on the embryonic expression of Xnkx-2.1, which is expressed in the presumptive forebrain from early neurulation onwards. In tadpole stage embryos Xnkx-2.1 transcripts are primarily detected in ventral forebrain, lung buds and thyroid anlage. Therefore, Xnkx-2.1 may be part of the genetic network that controls the early development of these organs.
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