| First Author | Peissel B | Year | 2000 |
| Journal | Mamm Genome | Volume | 11 |
| Issue | 11 | Pages | 979-81 |
| PubMed ID | 11063253 | Mgi Jnum | J:65393 |
| Mgi Id | MGI:1926529 | Doi | 10.1007/s003350010184 |
| Citation | Peissel B, et al. (2000) Linkage disequilibrium and haplotype mapping of a skin cancer susceptibility locus in outbred mice. Mamm Genome 11(11):979-81 |
| abstractText | Car-R (carcinogenesis-resistant) and Car-S (carcinogenesis-susceptible) outbred mice, obtained by phenotypic selection from an initial intercross of eight inbred strains, show a >100-fold difference in their susceptibility to two-stage skin tumorigenesis. We found that the lines carry a high degree of genetic polymorphism. with an average heterozygosity of 0.39. This polymorphism allowed the use of linkage disequilibrium (LD) and haplotype analysis for the mapping of a skin cancer modifier locus on Chr 7, in a short region of 6 cM, around the Tyr gene. Car-S mice inherited the susceptibility allele at this locus from the A/J, BALB/c, SJL/J, and SWR/J strains. Our results demonstrate the feasibility and usefulness of mapping disease genes by LD in phenotypically selected, genetically heterogeneous animals. |
