| First Author | Bryda EC | Year | 2001 |
| Journal | Genomics | Volume | 73 |
| Issue | 3 | Pages | 338-42 |
| PubMed ID | 11350126 | Mgi Jnum | J:69655 |
| Mgi Id | MGI:1935041 | Doi | 10.1006/geno.2001.6538 |
| Citation | Bryda EC, et al. (2001) High-resolution genetic and physical mapping of modifier-of-deafwaddler (mdfw) and waltzer (cdh23(v)). Genomics 73(3):338-42 |
| abstractText | Modifier-of-deafwaddler (mdfw) and waltzer (Cdh23(v)) are loci on mouse chromosome 10 encoding factors that are essential for the function of auditory hair cells. The BALB/cByJ-specific mdfw allele encodes a necessary and sufficient modifier that induces progressive early onset hearing loss in CBy-dfw(2J) heterozygotes. Recessive mutations in the waltzer locus result in circling behavior and congenital deafness. In this report we present a high-resolution integrated genetic and physical map of mdfw and Cdh23(v). Our genetic analyses localize mdfw between markers D10Mit60 and 148M13T7 within a 1.01-cM region. The Cdh23(v) critical interval is fully contained within the mdfw region and localizes between markers 146O23T7 and 148M13T7 within a 0.35-cM interval that is represented in an approximately 500-kb BAC contig. Our data suggest that mdfw and Cdh23(v) are allelic. Copyright 2001 Academic Press. |
