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Publication : Cloning and characterization of a novel human leptin receptor overlapping transcript-like 1 gene (LEPROTL1).

First Author  Huang Y Year  2001
Journal  Biochim Biophys Acta Volume  1517
Issue  2 Pages  327-31
PubMed ID  11342119 Mgi Jnum  J:67319
Mgi Id  MGI:1930382 Doi  10.1016/s0167-4781(00)00266-9
Citation  Huang Y, et al. (2001) Cloning and characterization of a novel human leptin receptor overlapping transcript-like 1 gene (LEPROTL1). Biochim Biophys Acta 1517(2):327-31
abstractText  A new full-length cDNA encoding a novel protein was isolated from our human fetal brain cDNA library. The cDNA consists of 2701 bp and has a putative open reading frame encoding 131 amino acids which possesses a JAK binding site (Pro(46)-Ile-Pro(48) which is preceded by a cluster of hydrophobic residues) and is highly homologous to the leptin receptor gene-related protein (OB-RGRP). Northern blot analysis showed that this new gene is widely expressed in human tissues and radiation hybrid mapping placed the gene to human chromosome 8p21.1-8p21.2.
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