| First Author | Kligman LH | Year | 2001 |
| Journal | Melanoma Res | Volume | 11 |
| Issue | 4 | Pages | 319-24 |
| PubMed ID | 11479419 | Mgi Jnum | J:70918 |
| Mgi Id | MGI:2148457 | Doi | 10.1097/00008390-200108000-00001 |
| Citation | Kligman LH, et al. (2001) Melanoma induction in a hairless mouse with short-term application of dimethylbenz. Melanoma Res 11(4):319-24 |
| abstractText | Melanomas have been induced in hamsters and guinea pigs with short-term, low dose applications of dimethylbenz [a]anthracene (DMBA) alone. In mice, however, melanoma induction has required either croton oil or ultraviolet radiation promotion in addition to DMBA. In this study, we report the development of a malignant melanoma, with metastases, in a hairless mouse after six applications of 0.25% DMBA alone. At sacrifice, a large primary tumour with characteristics of intralesional transformation was present, along with numerous pigmented macules and papules. Metastases were present in lymph nodes and lungs. There was a marked similarity between this melanoma and its precursor lesions and those seen in an earlier, Weiser-Maple guinea pig model, which, in turn, resembled human melanoma. |
