| First Author | Meng X | Year | 2001 |
| Journal | Cancer Res | Volume | 61 |
| Issue | 8 | Pages | 3267-71 |
| PubMed ID | 11309277 | Mgi Jnum | J:68913 |
| Mgi Id | MGI:1933696 | Citation | Meng X, et al. (2001) Promotion of seminomatous tumors by targeted overexpression of glial cell line-derived neurotrophic factor in mouse testis. Cancer Res 61(8):3267-71 |
| abstractText | We show with transgenic mice that targeted overexpression of glial cell line-derived neurotrophic factor (GDNF) in undifferentiated spermatogonia promotes malignant testicular tumors, which express germ-cell markers. The tumors are invasive and contain aneuploid cells, but no distant metastases have been found. By several histological, molecular, and histochemical characteristics, the GDNF-induced tumors mimic classic seminomas in men, representing a useful experimental model for testicular germ-cell tumors. The data also show that a deregulated stimulation of a normal proto-oncogene by its ligand can be an initiative event in carcinogenesis. |
