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Publication : Localization of 54 rat genes, and definition of new synteny groups conserved in the human and the rat.

First Author  Szpirer C Year  2000
Journal  Mamm Genome Volume  11
Issue  9 Pages  729-35
PubMed ID  10967130 Mgi Jnum  J:71341
Mgi Id  MGI:2149840 Doi  10.1007/s003350010139
Citation  Szpirer C, et al. (2000) Localization of 54 rat genes, and definition of new synteny groups conserved in the human and the rat. Mamm Genome 11(9):729-35
abstractText  In order to improve the rat gene map and comparative mapping with the human and the mouse, we determined the chromosome localization of 54 rat genes. Most genes encode transcription factors or other regulatory proteins of cancer relevance. The human homologs of four genes were also assigned to their respective chromosome. These data generated anchor points between the recently established radiation hybrid maps and the genetic and cytogenetic maps. They improve comparative mapping between the rat, the mouse, and the human gene maps, and in particular they disclose four new synteny groups conserved in the rat and the human. These new localizations should also be useful for the identification of genes involved in the control of quantitative traits such as cancer susceptibility or diabetes.
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