| First Author | Suzuki T | Year | 2000 |
| Journal | Behav Genet | Volume | 30 |
| Issue | 6 | Pages | 447-53 |
| PubMed ID | 11523704 | Mgi Jnum | J:71166 |
| Mgi Id | MGI:2149256 | Doi | 10.1023/a:1010298701251 |
| Citation | Suzuki T, et al. (2000) Mapping quantitative trait loci for circadian behavioral rhythms in SMXA recombinant inbred strains. Behav Genet 30(6):447-53 |
| abstractText | SM/J and A/J inbred strain of mice have different characteristics in circadian behaviors such as free-running period (tau), phase relationship (psi) between light-dark cycles and activity rhythms, and amount of wheel-running activity. To determine the genes which affect these behaviors, a quantitative trait locus (QTL) analysis using SMXA recombinant inbred strains derived from SM/J and A/J mice was performed. Concerning tau, two regions on chromosomes (Chrs) 7 and 18 surpassed the genome-wide suggestive level. As for psi, one suggestive QTL was detected on Chr 7. The QTLs which affect daily activity counts under light-dark cycles and constant darkness were mapped to the same chromosomal regions on Chrs 1 and 17, respectively. The provisional QTLs detected in the present study might be useful for understanding the complex mechanism regulating circadian behaviors. |
