| First Author | Okada K | Year | 2000 |
| Journal | Life Sci | Volume | 66 |
| Issue | 16 | Pages | 1461-70 |
| PubMed ID | 10794493 | Mgi Jnum | J:71346 |
| Mgi Id | MGI:2149859 | Doi | 10.1016/s0024-3205(00)00463-x |
| Citation | Okada K, et al. (2000) Reduced interleukin-1 responsiveness in immune system and central nervous system of inbred polydipsic (STR/N) mice. Life Sci 66(16):1461-70 |
| abstractText | Inbred polydipsic mice (STR/N strain) have primary polydipsia. The previous studies found abnormalities in the central nervous system (CNS), especially in the hypothalamus and circumventricular organ. As a part of pursuing to find the cause of the polydipsia, we investigated immunological characteristics of STR/N mice, using the ICR strain of mice as control. Their thymic subset cells showed that CD4+CD8+ double positive cells were increased, CD4+ single positive cells were decreased and CD5 expression was deficient, compared to ICR mice. T cell proliferative response and interleukin (IL)-2 production caused by IL-1beta stimulation were reduced in STR/N mice than those in the ICR mice. In in vivo studies the degree of thymic atrophy and the increases in serum level of ACTH and corticosterone induced by intraperitoneal IL-1beta injection were much less in STR/N mice than those in controls. Furthermore, adipsic response also induced by IL-1beta injection was greatly reduced compared to their control mice. All these results suggest that the responsiveness to IL-1 is impaired both in the immune system and the CNS of STR/N mice. |
