| First Author | Verlaet M | Year | 2001 |
| Journal | Biochem Biophys Res Commun | Volume | 283 |
| Issue | 1 | Pages | 12-8 |
| PubMed ID | 11322760 | Mgi Jnum | J:71014 |
| Mgi Id | MGI:2148954 | Doi | 10.1006/bbrc.2001.4731 |
| Citation | Verlaet M, et al. (2001) Genetic imbalances in preleukemic thymuses. Biochem Biophys Res Commun 283(1):12-8 |
| abstractText | To understand the molecular mechanisms involved in preleukemia, the suppression subtractive hybridization method was used in a murine radiation-induced thymic lymphoma model. Seventeen mRNAs overexpressed in preleukemic thymuses were identified: mouse laminin binding protein (p40/37LBP), E25 protein, Rattus norvegicus clone BB.1.4.1, profilin, poly(A) binding protein (PABP), mouse high mobility group protein 1, topoisomerase I, clusterin, proteasome RC1 subunit, rat prostatein C3 and C1 subunits; two ESTs and four unknown genes. The overexpression of PABP, clusterin, profilin, and the p40/37LBP mRNAs was confirmed in preleukemic thymuses and can be related to some cellular events observed during the preleukemic period, i.e., alterations of cell cycle and apoptosis properties. The p40/37LBP and 67-kDa laminin receptor proteins were upregulated during the preleukemic period. The data suggest that additional studies on p40/37LBP and 67-kDa laminin receptor regulation are required to evaluate their potential role in the lymphoma prevention by TNF-alpha and IFN-gamma. Copyright 2001 Academic Press. |
