| First Author | Sommer C | Year | 2001 |
| Journal | Brain Res | Volume | 913 |
| Issue | 1 | Pages | 86-9 |
| PubMed ID | 11532251 | Mgi Jnum | J:72237 |
| Mgi Id | MGI:2152026 | Doi | 10.1016/s0006-8993(01)02743-3 |
| Citation | Sommer C, et al. (2001) Anti-TNF-neutralizing antibodies reduce pain-related behavior in two different mouse models of painful mononeuropathy. Brain Res 913(1):86-9 |
| abstractText | We investigated the anti-hyperalgesic effect of neutralizing antibodies (AB) to tumor necrosis factor-alpha (TNF) in two murine models of neuropathy, the chronic constrictive sciatic nerve injury (CCI) which has a strong epineurial inflammatory component, and the partial sciatic nerve transection (PST), a 'pure' nerve injury model. In both models a single AB injection intra-operatively as well as on day 4 reduced thermal hyperalgesia significantly, whereas mechanical allodynia was only reduced with intraoperative but not with delayed treatment. |
