| First Author | Brodie SG | Year | 2001 |
| Journal | Trends Genet | Volume | 17 |
| Issue | 10 | Pages | S18-22 |
| PubMed ID | 11585672 | Mgi Jnum | J:72294 |
| Mgi Id | MGI:2152258 | Doi | 10.1016/s0168-9525(01)02451-9 |
| Citation | Brodie SG, et al. (2001) BRCA1-associated tumorigenesis: what have we learned from knockout mice?. Trends Genet 17(10):S18-22 |
| abstractText | A series of allelic mutations in the tumor suppressor Brca1 have been created to study mechanisms underlying BRCA1-associated tumorigenesis. Brca1 is essential in maintaining genome integrity through its involvement in DNA damage repair, G(2)-M cell-cycle checkpoint and centrosome duplication. The loss of Brca1 is not sufficient for malignant transformation, rather, it triggers multiple genetic alterations, including the inactivation of p53 and activation of a number of oncogenes, that ultimately result in mammary tumorigenesis. |
